2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P10957
    Imapextide 3004569-93-8 98.13%
    Imapextide is a glucagon-like peptide-1 (GLP-1) receptor antagonist that can be used in hypoglycemia research.
    Imapextide
  • HY-P10965
    Zovaglutide 3013543-64-8 98%
    Zovaglutide (ZT002) is a long-acting, selective GLP-1 receptor agonist. Zovaglutide enhances albumin binding capacity via dual fatty acid chain modification. Zovaglutide exerts metabolic effects through central and peripheral GLP-1 pathways, thereby promoting satiety, reducing caloric intake and enhancing glucose-dependent insulin secretion, with no activity against GIP or glucagon receptors. Zovaglutide can be used in research on type 2 diabetes or obesity.
    Zovaglutide
  • HY-P11023
    E16-uPA24
    E16-uPA24 is a chimeric peptide targeting urokinase-type plasminogen activator receptor (uPAR). E16-uPA24 modifies senescent cells surface with polyglutamic acid, promoting immune cell-mediated responses through glutamate recognition. E16-uPA24 induces immune clearance of senescent cells and restores tissue homeostasis by enhancing immune cells recruitment and directly coupling senescent cells and immune cells. E16-uPA24 can be used for tissue degeneration, chronic inflammatory disease and age-related tumorigenesis research.
    E16-uPA24
  • HY-P11271
    Ribupatide 2940971-65-1 98.74%
    Ribupatide is a dual gastric inhibitory polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) receptor agonist. Enicepatide can be studied in antidiabetic research.
    Ribupatide
  • HY-P1347A
    RETF-4NA TFA 99.65%
    RETF-4NA TFA, a chymase-specific substrate, is a sensitive and selective substrate for chymase when free or bound to α2M.
    RETF-4NA TFA
  • HY-P1481A
    β-Casomorphin, human TFA 99.67%
    β-Casomorphin, human TFA (Human β-casomorphin 7 TFA) is an opioid peptide, acts as an agonist of opioid receptor.
    β-Casomorphin, human TFA
  • HY-P1556A
    Vasonatrin Peptide (VNP) TFA 98.79%
    Vasonatrin Peptide (VNP) TFA is a chimera of atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP). Vasonatrin peptide TFA possesses the venodilating actions of CNP, the natriuretic actions of ANP, and unique arterial vasodilating actions not associated with either ANP or CNP. Vasonatrin Peptide TFA protects the diabetic heart against ischemia-reperfusion injury by inhibiting ER stress via the cGMP-PKG signaling pathway.
    Vasonatrin Peptide (VNP) TFA
  • HY-P1871A
    Amylin (IAPP), feline TFA 98.75%
    Amylin (IAPP), feline TFA is a 37-amino acid polypeptide from feline. Amylin (IAPP), feline TFA is one of the major secretory products of β-cells of the pancreatic islets. Amylin (IAPP), feline TFA is a regulatory peptide, which inhibits insulin and glucagon secretion.
    Amylin (IAPP), feline TFA
  • HY-P1873B
    Phosphorylase Kinase β-Subunit Fragment (420-436) acetate 99.57%
    Phosphorylase Kinase β-Subunit Fragment (420-436) acetate is the β-Subunit fragment (peptide 430-436) of phosphorylase kinase. Phosphorylase kinase is a serine/threonine-specific protein kinase which activates glycogen phosphorylase to release glucose-1-phosphate from glycogen.
    Phosphorylase Kinase β-Subunit Fragment (420-436) acetate
  • HY-P2080C
    GIP (1-30)-Myr 98%
    GIP (1-30)-Myr is the Myr-modified GIP (1-30), which is a glucose-dependent insulinotropic polypeptide (GIP) fragment. GIP is an incretin hormone that stimulates insulin secretion and reduces postprandial glycaemic excursions. GIP (1-30) dose-dependently promotes insulin secretion over the range 10-9-10-6 M.
    GIP (1-30)-Myr
  • HY-P2093A
    S961 TFA
    S961 TFA is an high-affinity and selective insulin receptor (IR) antagonist with IC50s of 0.048, 0.027, and 630 nM for HIR-A, HIR-B, and human insulin-like growth factor I receptor (HIGF-IR) in SPA-assay, respectively.
    S961 TFA
  • HY-P2588A
    Osteocalcin (human) TFA 98%
    Osteocalcin (Osteocalcin (1-49)) (human) TFA is a vitamin K-dependent bone specific protein. Osteocalcin (human) TFA is chemotactic for several of the cell types frequently found at bone remodeling surfaces.
    Osteocalcin (human) TFA
  • HY-P2733C
    Glycerol-3-phosphate oxidase, microorganism 9046-28-0
    Glycerol-3-phosphate oxidase, microorganism is an enzyme that catalyzes the oxidation of glycerol-3-phosphate to dihydroxyacetone phosphate, producing hydrogen peroxide in the process. Glycerol-3-phosphate oxidase is located in the mitochondria of microorganisms and is involved in the glycerol-3-phosphate cycle, regulating cellular energy metabolism. Glycerol-3-phosphate oxidase, microorganism can be used in conjunction with Lipoprotein Lipase and Glycerol Kinase to determine triglyceride levels.
    Glycerol-3-phosphate oxidase, microorganism
  • HY-P2800A
    Diaphorase, clostridium sp. 9001-18-7
    Diaphorase, Clostridium sp. is a diaphorase derived from Clostridium sp. As a flavin-containing NAD (P) H dehydrogenase, Diaphorase, Clostridium sp. uses NADH as an electron donor to reduce artificial dyes such as DCPIP and NBT, and participates in energy metabolism.
    Diaphorase, clostridium sp.
  • HY-P2907A
    Formate Dehydrogenase, Candida boidinii 98%
    Formate Dehydrogenase, Candida boidinii (EC 1.2.1.2) is involved in the stress response of plants and catalyzes the reduction of NAD+ to NADH.
    Formate Dehydrogenase, Candida boidinii
  • HY-P2921D
    Uricase, candida utilis 9002-12-4
    Uricase, candida utilis (Uox, candida utilis) is a uricase (urate oxidase) derived from Candida utilis. Uricase, candida utilis converts uric acid into allantoin. The absence of Uricase in mammals causes kidney diseases resulting from uric acid accumulation. Uricase, candida utilis can be used for research on chronic refractory gout and hyperuricemia.
    Uricase, candida utilis
  • HY-P2934A
    α-Ketoglutarate Dehydrogenase, Porcine
    α-Ketoglutarate dehydrogenase, Porcine (EC 1.2.4.2) is an enzyme complex that functions in the citric acid cycle.
    α-Ketoglutarate Dehydrogenase, Porcine
  • HY-P2950A
    α1-6 Mannosidase, Xanthomonas phaseoli 9025-42-7
    α1-6 Mannosidase, Xanthomonas phaseoli is a highly specific exoglycosidase that removes unbranched α1-6 linked mannose residues from oligosaccharides.
    α1-6 Mannosidase, Xanthomonas phaseoli
  • HY-P3019A
    Urocortin III (human) TFA
    Urocortin III (human) TFA is a corticotropin-releasing factor (CRF)-related peptide. Urocortin III (human) TFA preferentially binds and activates CRF-R2 and has a discrete central nervous system and peripheral distribution. Urocortin III (human) TFA potently binds to type 2 CRF receptors, specifically mCRF2β (Ki = 13.5 nM) and rCRF2α (Ki = 21.7 nM), while demonstrating negligible affinity for hCRF1 (Ki >100 nM). Urocortin III (human) TFA mediates somatostatin-dependent negative feedback control of Insulin (human) (HY-P0035) secretion.
    Urocortin III (human) TFA
  • HY-P3506B
    Retatrutide acetate 99.69%
    Retatrutide (LY3437943) acetate is a triple agonist peptide of the glucagon receptor (GCGR), glucosedependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R). Retatrutide acetate inhibits human GCGR, GIPR, and GLP-1R with EC50 values of 5.79, 0.0643 and 0.775 nM, respectively. Retatrutide acetate can be used for the research of obesity.
    Retatrutide acetate
Cat. No. Product Name / Synonyms Application Reactivity